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BIMATOPROST

Bimatoprost, a hypotensive agent, is a synthetic amide analogue (prostamide) of the potent FP receptor agonist 17-phenyl-prostaglandin F(PGF). Bimatoprost was first reported in the early 2000s and marketed, among others, as LumiganTM.1 It is approved as the first-line treatment for glaucoma in the European Glaucoma Society guidelines.2

C2 PHARMA is the exclusive distributor of Bimatoprost manufactured by Laurus Labs Limited, one of the world’s leading API manufacturers.

USES

As 0.03% ophthalmic solution it is approved for treatment of ocular hypertension and glaucoma as well as for hypotrichosis of eyelashes.

MECHANISM OF ACTION

Although classified as a prostamide, Bimatoprost exhibits a similar mechanism of action as the prostaglandins. It lowers the IOP without significantly affecting the aqueous production rate and enhances the aqueous humor outflow, either by enhancing the pressure-sensitive (presumed trabecular) outflow pathway or by increasing the pressure-insensitive (uveoscleral) outflow.3

REFERENCES

  1. Woodward, D. F. Survey of Ophthalmology, 2001, 45, 337-345.
  2. European Glaucoma Society. Terminology and Guidelines for Glaucoma. 3rd ed. Savona: Dogma; 2008.
  3. Sheng Lim, K. et al. Ophthalmology, 2008, 115, 790-795.